A woman in her 60s and a man in his 80s with severe neovascular age-related macular degeneration experienced improved sight after receiving implants of stem cell-derived retinal pigment epithelium cells. "This study represents real progress in regenerative medicine and opens the door to new treatment options for people with age-related macular degeneration," said researcher Pete Coffey of University College London.
At a Donate Life Month celebration, Sue Landacre, a registered nurse and clinical coordinator at United Hospital Center in Bridgeport, W.Va., shared the story of the death of her 13-year-old son Jake 12 years ago and her decision to donate his eyes and tissue. "It's a rewarding thing. It's the last gift they can give and the last gift you can give for them," Landacre said.
Alberta Health officials said donor registrations rose by a factor of 10 after the crash of a bus carrying a youth hockey team in Canada that killed 16 people. Over five days, the Alberta Organ and Tissue Donation Registry logged 12,704 new registrations.
A single injection of two genetically modified, broadly neutralizing antibodies protected rhesus monkeys from infection with simian-human immunodeficiency virus for a median of 20 weeks, researchers reported in Nature Medicine. A single mutation introduced into each of two antibodies extended the antibodies' survival in the monkeys' bloodstreams and protected the monkeys for longer than the unmodified antibodies, both when administered alone and in combination.
Researchers surveyed 86 labs worldwide and found that although 93% used massively parallel sequencing platforms to identify variants in breast and ovarian cancer genes, 27 of the respondents mostly used Sanger sequencing to confirm genetic variants identified through other methods while six used Sanger as their only method. "Global best-practice guidelines for BRCA testing are needed to ensure consistency in testing for patients, regardless of where they obtain their testing," said study author Amanda Toland.
A vaccine for the Zaire strain of the Ebola virus developed by Merck resulted in high and stable antibody levels two years after vaccination as part of a trial carried out in Guinea. The findings were reported in The Lancet Infectious Diseases.
Health officials in Brazil are 10 million people short of the goal they set in January of vaccinating over 23 million people against yellow fever in the states of Bahia, Sao Paulo and Rio de Janeiro.
Aptose Biosciences touted the efficacy of its experimental drug CG'806 as a treatment for specific blood cancers, with preclinical data showing CG'806 was 10 times as potent as Daiichi Sankyo's quizartinib and had up to 6,000 times greater potency compared with AbbVie's Imbruvica, or ibrutinib. The data were presented at the annual meeting of the American Association for Cancer Research.
A partnership was reached by Illumina and Bristol-Myers Squibb to create and commercialize companion diagnostics for the pharmaceutical company's pipeline of oncology drugs. A diagnostic version of Illumina's TruSight Oncology 500 that will run on the NextSeq 550Dx is expected to be developed by the companies.
A study in The Lancet of 15,000 children in Tanzania found that piperonyl butoxide improved the ability of insecticide-treated bed nets to reduce malaria transmission. The prevalence of malaria was reduced by 44% in the first year of testing and 33% in the second, and the World Health Organization has recommended the new nets.