A placebo-controlled study in Diabetes Care found that type 2 diabetes patients treated with empagliflozin did not have an additional risk of lower-limb amputation. Researchers evaluated data from the EMPA-REG Outcome trial on 7,020 adults and found that those in the empagliflozin 10 mg and empagliflozin 25 mg groups also had similar risks for lower-limb amputations.
UK researchers analyzed data from the Concordance in Diabetic Foot Ulcer Infection study involving 250 patients, mean age of 64.3, and found that 52 had an amputation of some part of their foot, while 18 had peripheral revascularization and 10 underwent both procedures. The findings in Diabetic Medicine also revealed that 45 patients died by the 12-month follow-up period.
Decreases in A1C levels were greater among type 2 diabetes patients who received once-weekly omarigliptin for 24 weeks than for those receiving a placebo, with the omarigliptin group experiencing a persistent A1C reduction, according to a study in Diabetes Research and Clinical Practice. In the study of 329 adults, those in the omarigliptin group had no reported cases of symptomatic hypoglycemia, compared with four in the placebo group.
An analysis of over 500,000 patient records from University of Pittsburgh Medical Center hospitals showed that using an EHR-based clinical decision support tool to monitor patients' blood creatinine levels helped detect acute kidney injury and led to a 0.8% reduction in deaths from the condition and a 2.7% drop in dialysis rates. The findings were published in the Journal of the American Society of Nephrology.
Medicare's long-term sustainability is at risk due to rising health care costs, a shrinking taxpayer base and an increasing number of beneficiaries, according to an HHS report, and the CMS would need to substantially increase revenue or make drastic cuts in benefits to balance its budget. With growth in health care costs continuing to outpace growth in the taxable wages that fund Medicare and the ratio of taxpayers to Medicare-eligible Americans falling from 3:1 in 2016 to 2:1 by 2091, the program is expected to face a budget shortfall of $3.3 trillion over the next 75 years.
Policy experts at an American Enterprise Institute briefing said it is possible to reduce waste in the health care system to lower costs, and talked about why accountable care organizations have been slow to show cost savings. "The United States has spent $3.4 trillion dollars on care delivery, and I'm suggesting that half of that is recoverable waste, potentially," said Brent James, M.D., of the Institute for Healthcare Improvement.
PET/CT with the breakthrough radiotracer Zr-89-pertuzumab provided excellent imaging quality five to eight days after tracer administration in six patients with HER2-positive breast cancer, identified multiple sites of HER2-positive malignancies, and identified brain metastases as HER2-positive in two patients with both HER2-positive and HER2-negative primary breast cancers and brain metastases, according to a study in the Journal of Nuclear Medicine. The findings also showed the approach didn't result in adverse reactions and may be used in evaluating HER2 status of lesions inaccessible through biopsy and HER2 heterogeneity assessment, researchers said.
"Green powders" are a mix of dried and blended plants designed to provide vitamins and minerals in supplement form, and registered dietitian Vandana Sheth says many of the ingredients have been associated with better exercise endurance, diabetes management and cholesterol levels. Lori Zanini, RD, says green powders should not be used to replace whole plant foods and consumers should look for certified brands to ensure the actual ingredients match what is on the product label.
Pediatricians and other health care professionals should participate in efforts aimed at curbing weight discrimination among overweight and obese youths such as practicing role modeling and behavior change counseling, using sensitive language and creating a safe clinical environment as well as working with schools and families and using the media in advocating against weight stigma, according to a joint policy statement issued in Pediatrics by the American Academy of Pediatrics and The Obesity Society. Meanwhile, a study in Pediatrics found obesity-promoting behaviors in all 31 children's films from 2012 to 2015 it examined, while most contained weight-based stigma.
Overweight or obese women are more likely to be diagnosed with breast cancer after a tumor has grown to more than 2 centimeters and may need more frequent screenings, according to a study to be presented at the Radiological Society of North America's annual meeting. Women with a BMI higher than 25 have a poorer prognosis when breast cancer is diagnosed between regular screenings, compared with normal weight women.